The early use of IV (Intra venous)verapamil and nitrates in Acute Myocardial Infarction (AMI)

The early use of Intra Venous verapamil and nitrates and the effects on angiographic patency and infarct size in Acute Myocardial Infarction

Status

Completed

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000232538

Acronym

IVANA

Enrollment

300

Registered

2006-06-07

Start date

2005-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To assess if the early use of verapamil and Glyceryl trinitrate improves TIMI 3 flow(term used to state that blood flow through coronary artery is back to normal)Only the study pharmacist was unblinded to treatment allocation. Study drug was sealed in a box and allocated a number in lots of 10. Study staff would allocate the sealed box to the patient by number sequence. All study personel and persons involved in the clinical management of the patient were also blinded to treatment allocation.Emergency unblinding was available if required.

Interventions

IV verapamil 2 mg over 5 minutes or saline placebo and glyceryl trinitrate infusion 5mcg per minute( 8 mls per hour) and the patient has given informed consent.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Acute ST segment elevation myocardial infarction(STEMI) with primary Percutaneous Coronary Intervention.

Exclusion criteria

Contraindications to verapamil/glyceryl trinitrate.

Outcome results