PreFER MVP For Elective Replacement

PreFER MVP For Elective Replacement: Previously paced patients, coming in For Elective Replacement, using MVP (Managed Ventricular Pacing): to demonstrate the benefit of MVP in pacemaker and implantable carvioverter defibrillator (ICD) patients with a history of right ventricular pacing. The MVP function reduces unnecessary right ventricular pacing which has been shown to induce heart failure. Total mortality and heart failure hospitalization will be evaluated.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000168550

Enrollment

801

Registered

2006-05-11

Start date

2006-04-01

Completion date

Unknown

Last updated

2026-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This study protocol outlines the methodology and background behind the hypothesis that less ventricular pacing in a pacemaker and ICD is beneficial to the patients with a history of right ventricular pacing. This will be evaluated by comparing the rate of patient deaths and the need for hospitalizations when using less ventricular pacing vs. the normal, standard amount of ventricular pacing.

Interventions

Replacement of pacemaker or ICD with a new device featuring MVP. Results after a follow-up period of 2 years with MVP "ON" vs MVP "OFF" will be compared. At the end of the 2 years the doctor will determine which settings are preferred for the patient to be left on.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Patient with dual chamber pacemaker or ICD, paced for at least 2 years, who are due for a replacement of their device, male or female, who have signed the consent form or have a legal guardian willing to sign the consent form.

Exclusion criteria

Patient with cardiac resynchronization therapy indications, or permanent atrial fibrillation, or permanent atrioventricular block.

Outcome results