A comparison of ketorolac with morphine in the treatment of acute renal colic

A prospective randomised controlled trial comparing the efficacy of intravenous morphine, intravenous ketorolac and the combination of these medications in acute renal colic in the emergency department

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000146594

Enrollment

150

Registered

2006-04-27

Start date

2006-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The purpose of this project is to help determine the most effective way to treat the acute pain associated with passage of a kidney stone. Standard treatment for renal colic involves the use of intravenous morphine titrated to effect. This study will involve comparison of intravenous morphine with ketorolac. This agent is a non-steroidal anti-inflammatory drug which will be given intravenously. In this study, patients will be given morphine, ketorolac or a combination of both of these medications. The hypothesis that is being tested is that ketorolac provides superior pain relief to morphine in acute renal colic. This is a double blinded study - both the treating doctors and the patients will be blinded to the interventions administered

Interventions

ketorolac tromethamine - single 30mg intravenous dose

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 60 Years

Healthy volunteers

Inclusion criteria

Able to give informed consentsuspected diagnosis of renal colic on presentation.

Exclusion criteria

Pregnancy or breast feedinghistory of renal impairment (including renal transplant)hepatic impairmentbleeding diathesisactive peptic ulcer diseasehypersensitivity to aspirin or nonsteroidal antiinflammatory drugshypersensitivity to morphinecurrently taking lithium or methotrexatesuspected volume depletion based on clinical examinationnon-English speaking (unfortunately funding limitations make it impossible to provide consent forms and information in languages other than English).

Outcome results