None listed
Conditions
Brief summary
Myocardial infarction remains common and early sequelae include adverse heart function, decompensation and increased death particularly over the first 3 months after a heart attack. This study aims to: (1) provide detailed information regarding early changes in heart function and hormones in patients who suffer heart attacks and do not have a successful early intervention to restore normal blood flow to the heart .(2) assess the potential benefit of infused BNP hormone on heart function, hormone status and cardiovascular outcomes over the 3 months following a heart attack.
Interventions
60 hours of infused BNP at a dose of 0.010g/kg/minute.
Sponsors
Health Research Council
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Diagnosis
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Healthy volunteers
No
Inclusion criteria
Who have completed acute myocardial infarction confirmed by typical clinical presentation, ischaemic ECG changes (including ST elevation) and definite rise and evolving pattern of cardiac markers indicative of failed early perfusion, LV regional wall motion abnormality. Patients will be enrolled within 12-48 hours after the onset of symptoms. At the time of initiation of placebo or BNP infusions, blood pressure is to be >100 mmHg systolic and heart rate < 100 bpm.
Exclusion criteria
Inability to give informed consent, unavailability of follow-up, evolving shock, unstable cardiac rhythm, haemodynamic parameters that fall outside those listed in the inclusion criteria.
Outcome results
None listed