The High Flow Oxygen Therapy Study

A pilot study to validate the use of high flow humidified oxygen therapy in a Cardiothoracic and Vascular Intensive Care Unit (CVICU), in patients requiring supplemental oxygen to treat hypoxia as assessed by arterial blood gas (PaO2).

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000139572

Acronym

The HOT Study

Enrollment

Registered

2006-04-24

Start date

2006-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Nasal prong oxygen therapy has several advantages over face mask oxygen such as: improved comfort and the ability to eat and talk while wearing the device. Warming and humidifying inspired gases means that high gas flows are able to be used. High gas flows delivered to the nose may mean that oxygen delivery is more efficient, however this has not been shown in cardiothoracic patients. We intend to assess whether this new system means that patients are able to be transferred to the ward more quickly.

Interventions

Patients meeting the inclusion criteria will be randomised to receive oxygen via a high flow humidified nasal interface. Once randomised, patients will remain on that mode of delivery until they are weaned/discontinued. Patients will be set to a target SpO2 of 95% and data from the patients' clinical charts recording arterial blood gas measurements, heart rate and respiratory rate will be taken at standard time points. Patient length of ICU stay from point of randomisation will be recorded.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Consent has been obtained or is likely to be obtained- Patient currently on oxygen therapy via nasal prongs or mask- In the opinion of the treating clinical team the patient has sub optimal gas exchange and/or the patient is in a degree of mild respiratory distress.

Exclusion criteria

The patient is likely to require imminent intubation (within 30mins)- The patient has a tracheostomy in situ- Patient would not be offered mechanical/non invasive ventilation due to clinical condition/prognosis- The patient has previously been enrolled in this study- The patient has already been treated with high flow nasal oxygen in the CVICU or Ward 42 this admission- Contraindication to high flow nasal oxygen.

Outcome results