Vasoactive peptides: regional plasma concentrations and correlation with cardiac haemodynamic status.

An observational study of the regional concentrations of vasoactive neurohormones in patients with cardiovascular disease, and their assocation with concurrent haemodynamic status.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12606000136505

Acronym

GRADIENT study

Enrollment

100

Registered

2006-04-20

Start date

2006-03-31

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

In 100 individuals with known or suspected heart disease we propose to describe the trans-cardiac (ie difference between circulation supplying heart and draining heart) and trans-organ (ie across the circulation of an organ) gradients of an array of circulating proteins of known and potential significance in heart disease. The study will determine whether these proteins are formed or eliminated by each organ studied and extend the knowledge of the metabolism of these proteins within the body.

Interventions

This is a cross-sectional and observational study. Regional transorgan arterial and venous blood sampling during diagnostic and interventional coronary angiography will be performed. Plasma will be assayed for neurohormones. Results will be correlated with invasive haemodynamic measures taken at the time of the angiogram.

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

1) Individuals requiring diagnostic or interventional coronary angiogram.

Exclusion criteria

:1) Clinical contraindication to invasive coronary angiographic or percutaneous procedures2) Hypotension (systolic blood pressure<100mmHg)3) Anuria4) Requirement for emergency percutaneous intervention where obtaining research samples might delay treatment.

Outcome results