The neuro-behavioural effects of Dexmedetomidine Vs Morphine in adult patients after cardiac surgery

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000084583

Enrollment

300

Registered

2006-03-01

Start date

2004-08-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Patients will receive intravenous morphine 30-70 mic/kg/hr infusion, up to 48hrs.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

Patients undergoing cardiac surgery on bypass including CABG, valve surgery, combination CABG and/or valve replacement procedures.·Patients who have given consent.

Exclusion criteria

Allergy to any of the trial drugs.·Creatinine >134 mmol/L or creatinine clearance calculated by Cockcroft Gault formula of <50ml/min·Receiving other alpha 2 agonists like Clonidine.·Patients on psychotic drugs other than night time hypnotics.·Pre operative dementia/ Parkinsonism/ Other cerebral illness.·Non English speaking patients.·Weight greater than 150 Kgs.·Surgery involving intracranial vasculature within last 3 months·Surgery involving free flap within last 3 months ·Receiving neuromuscular blockers for reasons other than performing endotracheal intubation.·Patients receiving regional analgesia·Haemodynamic instability, i.e. HR < 55 beats per minute, Systolic blood pressure < 90 mmHg.·Failure to obtain consent.

Outcome results