None listed
Conditions
Interventions
This is a two centre observational study in which the sensitivity and specificity of novel urinary and plasma biomarkers will be compared with conventional indicators of acute renal failure. Biomarkers will be assessed with varying degrees of frequency. 6 or 12 hourly measurements of novel and conventional biomarkers will be undertaken for the first 24 hours after admission to the intensive care unit. Thereafter, samples will be collected on a daily basis for the next 6 days (or until the patien
This is a two centre observational study in which the sensitivity and specificity of novel urinary and plasma biomarkers will be compared with conventional indicators of acute renal failure. Biomarkers will be assessed with varying degrees of frequency. 6 or 12 hourly measurements of novel and conventional biomarkers will be undertaken for the first 24 hours after admission to the intensive care unit. Thereafter, samples will be collected on a daily basis for the next 6 days (or until the patient is discharged from the intensive care unit. Patients reaching a pre determined Gamma-Glutamyl Transpeptidase (GGT)/Alkaline Phosphatase (AP) index will be enrolled in a second study (see entry for EARLY ARF 2).
Sponsors
Health Research Council of New Zealand
Eligibility
Sex/Gender
All
Age
16 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. (cardio-thoracic surgery sub group) Undergoing cardio-thoracic surgery involving cardiac-pump bypass plus one or more of the following:a) diabetesb) extra-cardiac vascular diseasec) creatinine >150 µmol/L 3 (General ICU admissions) consecutive admissions.
Exclusion criteria
\1. expected length of stay <24 hours2. The patient is not expected to survive longer than 72 hours3. Frank haematuria4. active cytotoxic chemotherapy in progress5. Patient has rhabdomyolysis and/myoglobinuria6. Patient is already receiving renal replacement therapy7. Consent is unobtainable8. Pre-existing severe renal disease (serum creatinine of >0.345 mmol/L) or a rise of >3 times from baseline serum creatinine (if available)9. Anuria or output less than 0.3 ml/Kg/hr at 4 hours after admission (following correction if underfilled).
Outcome results
None listed