The effect of serotonin receptor antagonists on delirium after coronary artery bypass graft surgery.

Status

Not yet recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12606000006549

Acronym

SERIOUS-D: Serotonin Receptor Inhibition OUtcome after Surgery- Delirium

Enrollment

100

Registered

2006-01-04

Start date

2006-06-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

To investigate a commonly used anti-nausea drug, tropisetron, and its application to preventing post-cardiopulmonary bypass delirium.

Interventions

Participants will receive tropisetron in the first 5 post-operative days. Investigating the use of tropisetron vs placebo on the incidence of post-cardiopulmonary bypass related delirium in the first 5 post-operative days. A pilot study of 100 patients in the early post-operative phase.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

60 Years to No maximum

Healthy volunteers

Inclusion criteria

All patients undergoing coronary artery bypass graft (CABG) surgery, requiring cardiopulmonary bypass (CPB).

Exclusion criteria

Pre-existing delirium, drug/alcohol abuse, age<60 years, haemodynamic instability pre-operatively, acute or evolving myocardial ischaemia.

Outcome results