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Diet and weight loss in men

The effect of a high protein low carbohydrate compared to a high carbohydrate diet moderate protein diet on weight loss and wellbeing in obese men

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12606000002583
Enrollment
120
Registered
2006-01-03
Start date
2005-03-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

The replacement of dietary carbohydrate with protein, combined with a low intake of fat, has been shown to induce larger weight loss in overweight participants when compared with conventional high carbohydrate/low fat diets and is an increasingly popular method for weight loss among the general public, suggesting this is a favourable weight loss regime for overweight people. There are concerns over the safety of the use of high protein-red meat diets, as red meat, although controversial, is proposed to increase the risk of colon cancer. Although a high protein-red meat diet may be associated with increasing the risk of colon cancer due to the higher content of meat, such a diet is also associated with weight loss and improved insulin sensitivity, which reduce colon cancer risk. From this it can be suggested that a higher protein dietary pattern used for weight loss that remains low in fat and high in fibre rich foods, in association with moderate exercise may not increase the risk of colon cancer. The impact of long term use of high protein-red meat diets on colon cancer risk has not been assessed. This study will assess the safety of high protein-red meat diets as a method for weight loss in overweight participants. It will also investigate a series of secondary outcomes that impact on total health status.

Interventions

Participants assigned to a high protein (35% of energy) for 12 months.

Sponsors

Meat and Livestock Australia
Lead SponsorCommercial sector/Industry

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
20 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

Have at least one CVD risk factor other than obesityBMI 27-40kg/m2

Exclusion criteria

Use of any form of drug therapy or medication or supplements on a regular basis that may interfere with bowel function (e.g. laxatives, antibiotics, anti-diarrhoeals or probiotics)Consumption of any over-the-counter medication that in the opinion of the investigator could interfere with the study.History or presence of gastrointestinal, renal or hepatic disease of any cause.

Outcome results

None listed

Source: ANZCTR · Data processed: Mar 1, 2026