Overnight Effects of nCPAP with and without humidification on upper airway function.

Overnight Effects of nCPAP with and without humidification on: inspiratory temperature, humidity, mouth leak, saccharine transit time, nasal lavage and in vitro mucus properties in patients with obstructive sleep apnea.

Status

Not yet recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000800628

Acronym

TS-LOREa

Enrollment

Registered

2005-12-21

Start date

2006-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Participants will be randomised to 3 consecutive nights (Monday, Wednesday and Friday) of CPAP for one night CPAP + (conventional heated humidification) for one night CPAP + (optimal level of humidity) for one night Outcome measures:(all measured pre and post each overnight study) Saccharine transit time Mucus physical properties Cytology via lavage Inflammatory mediators Upper airways symptom score

Interventions

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Moderate to severe obstructive sleep panea > 15 AHI > 75% of events must be obstructiveExcessive daytime sleepiness (ESS > 10).

Exclusion criteria

Nasal CPAP intolerance determined in the PSG-CPAP titration studyacute upper airway diseasesmokerCOPDCongestive heart failure.

Outcome results