Deep breaths and airway closure in asthma

Effect of inhaled surfactant on the magnitude of bronchoprotection by deep inspiration against methacholine induced airway narrowing in asthmatic and non-asthmatic subjects

Status

Withdrawn

Phases

Phase 2

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000790640

Enrollment

Registered

2005-12-14

Start date

2006-02-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Poractant alfa, 120mg delivered by aerosolization of a 50mg/ml suspension in 0.9% normal saline, on two occasions administered 30 minutes before bronchial challenge with methacholine chloride.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Asthma, defined by previous doctor diagnosis and current symptoms or regular therapyNon-asthmatic controls with no history of asthma or other chronic respiratory disease.

Exclusion criteria

Smokers and subjects who are otherwise unsuitable for bronchial challenge will be excluded.

Outcome results