DETECTION OF EARLY CARDIAC (ASYMPTOMATIC) DISEASE BY B-TYPE NATRIURETIC PEPTIDE (DETECT STUDY).

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12605000736640

Acronym

DETECT

Enrollment

102

Registered

2005-11-11

Start date

2005-02-01

Completion date

2005-12-13

Last updated

2025-09-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a pilot study to test the ability of the heart hormones plasma NT-proBNP and/or BNP to distinguish early structural and/or functional cardiac changes in asymptomatic subjects at risk of later adverse cardiac outcomes. 100 people in all will be invited to take part. Fifty will be asymptomatic, aged 45-65 years with treated or untreated hypertension of 10 or more years duration any of whom may or may not have additional risk factors, including diabetes, dyslipidaemia, obesity. None of these subjects will have any overt cardiovascular medical history. The other fifty people will be age, gender and BMI-matched unmedicated controls with no history of cardiovascular risk factors or events and with normal findings on physical examination. Both groups will have normal renal function. All participants will be asked to attend one outpatient clinic for: Full medical history. Physical examination including full cardiovascular examination and recording of age, gender, height, weight, waist circumference, heart rate, blood pressure, heart sounds and venous pressure. Recording of any medications. Routine haematology, biochemistry including haemoglobin, white cell count, creatinine, Na, K, fasting sugar and lipid profile. Echocardiography with full assessment of dimensions and both systolic and diastolic function. Blood sampling for plasma BNP and NT-proBNP A second attendance will be required for a Cardiac magnetic resonance scanning to measure left ventricular mass will be performed.

Interventions

None.

Eligibility

Sex/Gender

All

Age

45 Years to 65 Years

Healthy volunteers

Inclusion criteria

Study Population: Fifty asymptomatic patients aged 45-65 years with treated or untreated hypertension of 10 or more years duration any of whom may or may not have additional risk factors, including diabetes, dyslipidaemia, obesity. No patient will have incurred any overt cardiovascular event (ie. no acute coronary syndrome, no stable angina, no heart failure, no cerebrovascular events and no peripheral arterial events).Control Group: Fifty age, gender and BMI-matched unmedicated controls with no history of cardiovascular risk factors or events and with normal findings on physical examination. Both groups will have normal renal function.

Exclusion criteria

No exclusion criteria

Outcome results