None listed
Conditions
Interventions
This project is to assess the relative effectiveness of two clinically applicable algorithms to guide titration of ICS therapy in subjects with asthma. The effectiveness of the algorithm will be assessed in terms of its capacity to minimise long-term ICS (and oral steroid) usage while maintaining optimal asthma control (asthma-free days and quality of life).Down titration of ICS according to pre-set clinical criteria for well controlled asthma (usual care) or levels of exhaled nitric oxide (eNo)
This project is to assess the relative effectiveness of two clinically applicable algorithms to guide titration of ICS therapy in subjects with asthma. The effectiveness of the algorithm will be assessed in terms of its capacity to minimise long-term ICS (and oral steroid) usage while maintaining optimal asthma control (asthma-free days and quality of life).Down titration of ICS according to pre-set clinical criteria for well controlled asthma (usual care) or levels of exhaled nitric oxide (eNo).
Sponsors
CRC for Asthma
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Asthma must be well controlled over the two weeks prior to entry on ICS > 100 mcgs fluticasone or equivalent daily + LABA (salmeterol or formoterol), with medication dose stable for four weeks prior to entry. a.FEV1 criterion for well controlled asthma at entry: FEV1 must be within 10% of the best within the last 2 years, and equal to or above 65% of predicted FEV1 b.Maximum reliever use must be 3 times weekly (excluding prophylactic use for exercise) at Visit 1.
Exclusion criteria
No exclusion criteria
Outcome results
None listed