None listed
Conditions
Brief summary
Diabetic patients will be randomised to receive one of two commonly used anaesthetic drugs to maintain general anaesthesia whilst on cardiopulmonary bypass. We will be investigating which one offers better cardioprotection as determined by measuring an enzyme called cardiac troponin i. This enzyme is commonly measured to detect whther a myocardial infarction "heart attack" has occurred.
Interventions
A comparison of 2 different anaesthetic agents (propofol and sevoflurane) and their affect on cardioprotection in non insulin diabetic patients undergoing coronary artery bypass graft surgery requiring cardiopulmonary bypass. 2 groups of 20 patients each will be randomised to receive either propofol or sevoflurane to maintain general anaesthesia whilst on cardiopulmonary bypass. Anaesthesia leading up to bypass will be the same in each group. At 15 minutes post separation from bypass, both gr
A comparison of 2 different anaesthetic agents (propofol and sevoflurane) and their affect on cardioprotection in non insulin diabetic patients undergoing coronary artery bypass graft surgery requiring cardiopulmonary bypass. 2 groups of 20 patients each will be randomised to receive either propofol or sevoflurane to maintain general anaesthesia whilst on cardiopulmonary bypass. Anaesthesia leading up to bypass will be the same in each group. At 15 minutes post separation from bypass, both groups will receive sevoflurane anaesthesia alone. Otherwise, management will be as per normal for coronary artery bypass patients.
Sponsors
Dept of Anaesthesia
Study design
Allocation
Randomised controlled trial
Intervention model
Other
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
0 to 80 Years
Healthy volunteers
No
Inclusion criteria
Non insulin dependent diabetes mellitus patients, undergoing routine, primary coronary artery bypass graft surgery requiring cardiopulmonary bypass.
Exclusion criteria
Those with a sensitivity to propofol or its components, acute or evolving myocardial infarction, peroperative haemodynamic instability, hepatorenal dysfunction, off pump or valvular surgery.
Outcome results
None listed