None listed
Conditions
Brief summary
1. This study will examine the use and safety of FB and BAL to identify lower respiratory tract infection (especially PA) in infants and young children with CF and direct therapy in an attempt to eradicate proven early lung infection. 2. The role of infection and inflammation in the development of CF lung disease will be examined in a large cohort of CF infants recruited prospectively and followed longitudinally.
Interventions
This study is designed to examine: 1.The clinical value, safety and cost effectiveness of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) to identify lower respiratory tract infection (especially Pseudomonas aeruginosa (Pa)) in infants and young children with cystic fibrosis (CF) and to direct therapy in an attempt to eradicate proven early lung infection and delay progressive lung disease. 2. The role of and relationship between lower respiratory infection and inflammation in the de
This study is designed to examine: 1.The clinical value, safety and cost effectiveness of flexible bronchoscopy (FB) and bronchoalveolar lavage (BAL) to identify lower respiratory tract infection (especially Pseudomonas aeruginosa (Pa)) in infants and young children with cystic fibrosis (CF) and to direct therapy in an attempt to eradicate proven early lung infection and delay progressive lung disease. 2. The role of and relationship between lower respiratory infection and inflammation in the development and pathophysiology of lung disease in a large cohort of CF infants recruited prospectively and followed longitudinally.
Sponsors
NHMRC
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to 6 Months
Healthy volunteers
No
Inclusion criteria
All infants diagnosed with cystic fibrosis through the neonatal screening program in Queensland, New South Wales, South Australia, Victoria, Auckland and North Auckland Infants diagnosed with meconium ileus may be enrolled when diagnosis of cystic fibrosis is confirmed. A diagnosis of cystic fibrosis must be confirmed with a positive sweat chloride (Gibson Cooke with a chloride > 60mmol/l).Informed consent from parents or guardians.
Exclusion criteria
Informed consent cannot be obtained. Infant is severely ill at the time of diagnosis and requires ventilatory support. Family are planning to move overseas in the next few years.
Outcome results
None listed