Milrinone for Free Flap Surgery

Milrinone versus placebo infusion intraoperatively to prevent vasospasm during free flap surgery

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000640606

Enrollment

100

Registered

2005-10-13

Start date

2002-05-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Double-blind, randomised control trial comparing free flap surgery outcomes after intra-operative Milrinone or placebo at 0.25ug/kg/min infusion during anaesthesia with a 25ug/kg bolus over 20 minutes after induction of anaesthesia.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Elective patients for free flap surgery.Serious cardiac disease, stenotic or ischaemic cardiac disease and history of ventricular arrhythmias.Previous adverse reaction or allergy to milrinone.Renal impairment Cr > 0.15 mmol/L.

Exclusion criteria

Inability to give informed consent and patient refusal.

Outcome results