Effect of preoperative atenolol on morality and cardiovascular morbidity after non-cardiac surgery.

A prospective, double-blind randomised control study comparing the effect of atenolol versus placebo on mortality and cardiovascular morbidity in patients undergoing non-cardiac surgery.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000639628

Enrollment

200

Registered

2005-10-13

Start date

2000-12-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Double-blind, randomised control trial comparing atenolol or placebo given preoperatively and for 7 days postoperatively. Patients are telephoned at 3 months, 6 months, 12 months and 2 years postoperatively to follow up on mortality and cardiovascular morbidity.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Any patient undergoing major surgery under general anaesthesia who has at least 2 of the following risk factors for coronary artery disease: diabetes, hypertension, current smoker, cholesterol > 6.2mmol/L.

Exclusion criteria

Known coronary artery disease, long term beta-blocker use, poorly compensated CCF, 3rd degree heart block, inducible bronchospasm (unstable asthma).

Outcome results