None listed
Conditions
Brief summary
To determine whether doubling inhaled corticosteroids at the first sign of a cold or of asthma deterioration in children on preventive treatment with inhaled corticosteroids leads to a reduced need for oral steroid rescue or reduced risk of admission to hospital. To examine the effect of doubling the dose of inhaled corticosteroids at the first sign of a cold or asthma deterioration on the growth of children on preventive treatment for asthma.
Interventions
Double blind, placebo-controlled, parallel, multi-centre trial. Children will be regularly on inhaled Fluticasone Propionate. Children will be randomised to receive either double their usual dose of inhaled corticosteroids or their usual dose of inhaled corticosteroid + placebo with intercurrent upper respiratory infections or exacerbations of their asthma for the following 12 months.
Children aged 6 years or older will be asked to perform spirometry at all visits. Peak flow measurements wil
Double blind, placebo-controlled, parallel, multi-centre trial. Children will be regularly on inhaled Fluticasone Propionate. Children will be randomised to receive either double their usual dose of inhaled corticosteroids or their usual dose of inhaled corticosteroid + placebo with intercurrent upper respiratory infections or exacerbations of their asthma for the following 12 months. Children aged 6 years or older will be asked to perform spirometry at all visits. Peak flow measurements will also be recorded. Height and weight will be measured using standard equipment (Harpenden stadiometer or equivalent) that will be consistent for each centre at each visit.
Sponsors
Asthma Foundation Queensland
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
3 Years to 14 Years
Healthy volunteers
No
Inclusion criteria
Currently using 125mcg or greater of inhaled Cortico-steroid dailyExacerbation of asthma in past 12/12 requiring Oral Steroid
Exclusion criteria
Children with other respiratory diseases such as cystic fibrosis. Children with other significant medical conditions that may affect growth.
Outcome results
None listed