None listed
Conditions
Brief summary
This study has been designed to examine where first infections with Pseudomonas aeruginosa come from and also to examine the factors that may be important in how the organism might be passed from one person to another with CF.
Interventions
This project is divided into four parts. Part one is designed to examine whether early acquisition of P.aeruginosa in young children with CF is associated with environmental sources of P.aeruginosa in the home. Part two is a methodology study designed to screen large numbers of microbiological samples for the predominant Brisbane clonal strain of P.aeruginosa. Part three allows an opportunity to explore the possible relationship between molecular factors that may be involved in acquisition and t
This project is divided into four parts. Part one is designed to examine whether early acquisition of P.aeruginosa in young children with CF is associated with environmental sources of P.aeruginosa in the home. Part two is a methodology study designed to screen large numbers of microbiological samples for the predominant Brisbane clonal strain of P.aeruginosa. Part three allows an opportunity to explore the possible relationship between molecular factors that may be involved in acquisition and transmission of clonal strains of P.aeruginosa. Part four examines culturable cough generated aerosols in patients with CF and an examination of clinical factors that may be involved in aerosol transmission of P.aeruginosa. It is anticipated that environmental sampling may take up to 2 years to complete and that clinical air sampling will take up to 12 months to complete.
Sponsors
A/Prof Claire Wainwright
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Children and adults diagnosed with cystic fibrosis at Royal Children's Hospital, Brisbane and The Prince Charles Hospital, Brisbane Informed consent from patients or parents/guardians.
Exclusion criteria
Informed consent cannot be obtained.
Outcome results
None listed