Use of a local anaesthetic wound infusion to reduce morphine requirements following major abdominal surgery

Status

Terminated

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000603617

Enrollment

Registered

2005-10-05

Start date

2005-11-01

Completion date

2006-05-01

Last updated

2024-08-19

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Use of ropivacaine via Stryker(R) Pain Pump system for 48 hours post-op to decrease the amount of PCA morphine required following major abdominal surgery requiring midline laparotomy.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

American Society of Anesthesiology (ASA) physical status 1, 2 or 3 patients undergoing elective major abdominal surgery via midline laparotomy at Geelong Hospital.

Exclusion criteria

Pregnant; weight <50kg; allergy to morphine or amide local anaesthetics; ASA physical status 4; severe renal disease ( eGFR < 40ml/min ); significant hepatic impairment; severe respiratory disease (FEV1 < 1.0 l) cognitive impairment or a history of chronic opioid use. Furthermore, patients may be excluded from the trial immediately post-operatively if they meet any of the following criteria: patients who remain intubated post-operatively; post-operative renal or hepatic failure; morphine intolerance or major surgical complications requiring a return to theatre such as sepsis, bleeding or anastomotic breakdown.

Outcome results