The effect of parecoxib on post craniotomy analgesia.

A prospective randomised controlled, double-blind study of Parecoxib versus placebo for postoperative analgesia following craniotomy surgery.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000600640

Enrollment

Registered

2005-10-05

Start date

2005-10-06

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

This prospective randomised controlled, double-blind study has been designed to examine if a single dose of Parecoxib 40mg decreases postoperative pain and morphine requirements for 24 hours following craniotomy surgery.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

Alert and orientated, patients presenting for elective craniotomy.

Exclusion criteria

Allergy or contraindication to NSAID's, sulphonamides or morphine.Combination ACE inhibitors and diuretics OR either an ACE inhibitor or diuretic if over 70 years oldAsthma if aggrevated by NSAID's or never taken NSAID'sSignificamt peptic ulcer diseaseRenal impairmentChronic pain conditions or taking oral morphine or NSAID's taken on day of surgeryNon English speaking or unable to understand Visual Analogue ScoreIschaemic Heart Diseae or Cerebrovascular DiseaseAny preoperative confusion or sedation.

Outcome results