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A pilot study of psychotherapeutic intervention for complex presentations of first-episode psychosis

A pilot study to evaluate the feasibility, safety and efficacy of psychotherapeutic intervention for comorbid BPD and first-episode psychosis

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12605000594628
Acronym
Mauve Zone
Enrollment
16
Registered
2005-10-05
Start date
2005-08-26
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

This is a pilot study of 16 sessions of Cognitive Analytic Therapy (CAT) (run over 16 weeks) compared to treatment as usual (TAU) for young people aged 15 to 24 years with co-occurring first episode psychosis and full or sub-threshold BPD. Patients who consent to be involved in the current study will be randomized to TAU or TAU + CAT. Measures will be undertaken at three time-points: baseline, end of treatment phase (for both conditions), and 6 month follow up. Measures include: demographics, a

This is a pilot study of 16 sessions of Cognitive Analytic Therapy (CAT) (run over 16 weeks) compared to treatment as usual (TAU) for young people aged 15 to 24 years with co-occurring first episode psychosis and full or sub-threshold BPD. Patients who consent to be involved in the current study will be randomized to TAU or TAU + CAT. Measures will be undertaken at three time-points: baseline, end of treatment phase (for both conditions), and 6 month follow up. Measures include: demographics, and standardized measures of diagnosis, psychopathology, psychosocial functioning, substance abuse, treatment adherence and service utilization.

Sponsors

Orygen Research Centre and Orygen Youth Health
Lead SponsorOther

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
15 Years to 25 Years
Healthy volunteers
No

Inclusion criteria

(1) Eligibility for EPPIC program, 1 week or more of psychotic symptoms with less than 6 months of active previous treatment (i.e., antipsychotic medication); and (2) Diagnosis of four or more DSM-IV BPD traits (APA, 1994).

Exclusion criteria

(1) Severe and enduring psychotic symptoms, defined as scores of 4 or more on 1 or more psychotic items of the Brief Psychiatric Rating Scale (BPRS) which have persisted for more than 1 month (Overall & Gorham, 1962); (2)Unable to converse in, or read English without an interpreter; (3) Intellectual deficits, such that unable to meaningfully participate in the psychotherapy; and (4) Already given informed consent for another psychotherapy trial at ORYGEN Youth Health, or already received a course of CAT.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026