PRACTICAL TRIAL

Platelet Responsiveness to Aspirin and Clopidogrel and Troponin Increase after Coronary intervention in Acute coronary Lesions

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000581662

Acronym

PRACTICAL

Enrollment

370

Registered

2005-10-04

Start date

2004-01-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A multi-centre, randomised, double-blind, clinical trial comparing a 600mg versus 300mg loading dose of Clopidogrel on the Incidence of Myonecrosis and Laboratory Measures of Platelet Inhibition following early Percutaneous Coronary Intervention in Acute Coronary Syndrome patients.

Interventions

Clopidogrel Loading Dose 300mg vs 600mg

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

1. abnormal electrocardiogram 2. evidence of myonecrosis (elevated troponin I or T above ULN) at presentation.3. known coronary artery disease with previous MI, PCI, CABG surgery, or positive stress test.

Exclusion criteria

No exclusion criteria

Outcome results