None listed
Conditions
Interventions
Patients who agree to participate in the study and fulfil the inclusion criteria will be randomised to one of two treatment groups.
1.Standard therapy group will receive high-carbohydrate low-fat enteral feed (16.7% protein, 30% fat and 53.3% carbohydrates) at a target rate as decided by the treating physician and dietician for a maximum of 5 days following randomisation.
2.Alternative therapy group will receive high-fat low-carbohydrate enteral feed (16.7% protein, 55.2% fat and 28.1% carbohydr
Patients who agree to participate in the study and fulfil the inclusion criteria will be randomised to one of two treatment groups. 1.Standard therapy group will receive high-carbohydrate low-fat enteral feed (16.7% protein, 30% fat and 53.3% carbohydrates) at a target rate as decided by the treating physician and dietician for a maximum of 5 days following randomisation. 2.Alternative therapy group will receive high-fat low-carbohydrate enteral feed (16.7% protein, 55.2% fat and 28.1% carbohydrates) at a target rate as decided by the treating physician and dietician for a maximum of 5 days following randomisation. All patients will receive enteral feeding by continuous flow for 24hrs/day. The decision to commence or cease enteral feeding will remain with the treating physician. The measurement of VO2, VCO2, resting energy expenditure and respiratory quotient will be made on all participants 12 hourly for a maximum of 5 days using the indirect calorimeter. The indirect calorimeter is connected to the expiratory outlet of the ventilator, collecting and analyzing gas that is normally discharged into the atmosphere.
Sponsors
Intensive Care Unit, RMH
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1.Adult patients admitted with acute respiratory failure (PaO2/FiO2 < 300), needing mechanical ventilation and who are expected to require mechanical ventilation for more than 48 hours.2.Patients who are to receive enteral feeding via a gastric or post-pyloric feeding tube.3.Patients or next-of-kin who consent to participate in the study.
Exclusion criteria
1.Patients under the age of 18 years.2.Patients with a contra-indication to enteral feeding.3.Patients receiving total parenteral nutrition.4.Patients who are not receiving active medical management or who are expected to die within 24 hours at the time of study entry.5.Patients with diabetes mellitus, renal failure or liver failure. 6.Patients who are already enrolled in another study that may influence the outcome of this study.7.Patients or next-of-kin who do not consent to participate in the study.
Outcome results
None listed