A Randomised Trial of DHA in pregnancy to prevent postnatal depressive symptoms and enhance neurodevelopment in children: The DOMInO Trial

Conditions

None listed

Brief summary

DHA is an omega-3 fat found in fish and fish oils and is thought to play a role in the way the brain works and develops. It has been suggested that supplementing the diet with DHA may reduce feelings of depression, while studies with young infants suggest that enriching the diet with DHA may also help improve visual development. While in the womb, the baby is supplied with DHA from the mothers circulation. The level of DHA in the mothers circulation is largely determined by the amount of DHA in the mothers diet. Australian women generally have low levels of DHA. This study will help determine whether increasing the amount of DHA in the diet improves outcome for women and their babies.

Karen P Best, Thomas Sullivan, Debra J. Palmer, Michael Gold, James A. Martin et al. (7 authors)

World Allergy Organization Journal2018-01-0143 citations

10.1186/s40413-018-0190-7

Effect of prenatal DHA supplementation on the infant epigenome: results from a randomized controlled trial.

van Dijk SJ, Zhou J, Peters TJ, Buckley M, Sutcliffe B, Oytam Y, Gibson RA, McPhee A, Yelland LN, Makrides M, Molloy PL, Muhlhausler BS.

2016-11-0458 citations

10.1186/s13148-016-0281-7

Does n-3 LCPUFA supplementation during pregnancy increase the IQ of children at school age? Follow-up of a randomised controlled trial

Jacqueline F. Gould, Karli Treyvaud, Lisa N Yelland, Peter J. Anderson, Lisa G. Smithers et al. (8 authors)

BMJ Open2016-05-0121 citations

10.1136/bmjopen-2016-011465

Higher cord blood 25-hydroxyvitamin D concentrations reduce the risk of early childhood eczema: in children with a family history of allergic disease.

Palmer DJ, Sullivan TR, Skeaff CM, Smithers LG, Makrides M, DOMInO Allergy Follow-up Team.

2015-10-0619 citations

10.1186/s40413-015-0077-9

Effect of n-3 long chain polyunsaturated fatty acid supplementation in pregnancy on infants' allergies in first year of life: randomised controlled trial.

Palmer DJ, Sullivan T, Gold MS, Prescott SL, Heddle R, Gibson RA, Makrides M.

2012-01-30141 citations

10.1136/bmj.e184

Maternal supplementation with docosahexaenoic acid during pregnancy does not affect early visual development in the infant: a randomized controlled trial.

Smithers LG, Gibson RA, Makrides M.

2011-04-1335 citations

10.3945/ajcn.110.009647

Effect of DHA supplementation during pregnancy on maternal depression and neurodevelopment of young children: a randomized controlled trial.

Makrides M, Gibson RA, McPhee AJ, Yelland L, Quinlivan J, Ryan P, DOMInO Investigative Team.

2010-10-01366 citations

10.1001/jama.2010.1507

Interventions

0.5g DHA rich Tuna Oil Capsules taken from 18-21 weeks until birth.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

No

Inclusion criteria

Singleton pregnancy of 18-21 weeks gestation; no known fetal abnormality; women with no documented history of alcohol or drug abuse; no participation in other clinical trials with fatty acid intervention.

Exclusion criteria

Bleeding disorders where DHA rich tuna oil is contraindicated.

Outcome results