Analgesia after major thoracic or abdominal surgery: A comparison of patient controlled analgesia with morphine versus tramadol versus morphine/tramadol combination

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000564651

Enrollment

Registered

2005-09-30

Start date

2004-01-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Paracoxib 40mg given shortly before end of surgery. PCA commenced in recovery. Study syringes contain either morphine 60mg in 30mls n.saline or tramadol 600mg in 30mls n.saline or mophine 30mgs and tramadol 300mg in n.saline. PCA pump set at 2mg/ml, 1mg bolus,5 minute lockout and no 4 hour dose limit. Inadequate analgesia treated with fentanyl. Study period 48 hours per subject. Computer generated randomisation by pharmacy.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

ASA 1-3, elective major thoracic or abdominal surgery requiring parental opiod analgesia.

Exclusion criteria

Clinically relevant liver or renal impairment, chronic pre-op opiod use, patients unsuitable for PCA, planned epidural analgesia, allergy to morphine, tramadol or paracoxib.

Outcome results