None listed
Conditions
Interventions
None, this is an observational study
It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patients white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals w
None, this is an observational study It remains unclear why some individuals are able to clear HBV from their bodies while in others HBV is a persistent infection. We plan to investigate this process by collecting blood and analysing how the patients white blood cells respond to different pieces of the HBV virus. We will use new tools that can precisely tell us which component of the immune response may be different in individuals who are chronically infected with HBV and also in individuals who are also infected with HIV.
Sponsors
NIH
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
There are two groups of patients in this study. Group A mono-infected with Hepatitis B, and those with co-infection HBV/HIV.Group A inclusion criteria: (also split into 6 recruiting groups)1- Acute hepatitis B2- Chronic hepatitis B, HBV DNA+ve , normal ALT , HBeAg +ve3- Chronic hepatitis B, HBV DNA +ve , normal ALT, HBeAg -ve4- Chronic hepatitis , HBV DNA +ve, increased ALT, no HBV treatment B, HBeAg +ve5- Chronic hepatitis B, HBV DNA +ve , increased ALT, no HBV treatment B, HBeAg -ve6- Chronic hepatitis B, undergoing 'flare' of hepatitis. Group B inclusion criteria:to be HIV/HBV co-infected.
Exclusion criteria
No exclusion criteria
Outcome results
None listed