None listed
Conditions
Brief summary
We aim to assess whether new combination therapies for malaria, based on artemisinin drugs and a chloroquine-like drug piperaquine, will be effective in children with malaria in Papua New Guinea
Interventions
Chloroquine/sulfadoxine/pyrimethamine
Dihydroartemisinin-piperaquine
Artesunate-piperaquine
Chloroquine
These drug regimes will be given by mouth in conventional doses over up to three days as treatment for malaria.
Sponsors
University of Western Australia
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
4 Years to 10 Years
Healthy volunteers
No
Inclusion criteria
Children with a history of fever and a blood film positive for either P. falciparum or P. vivax will be eligible provided that: i) they have no features of severe malaria,34 ii) there is no history of prior antimalarial drug use (quinine or artemisinin drugs within 7 days, or a 4-aminoquinoline, pyrimethamine and/or sulphonamide within 28 days), iii) there is no clinical evidence of another infection as a cause of fever, and iv) the childs parents or relatives give informed consent.
Exclusion criteria
No exclusion criteria
Outcome results
None listed