Randomized controlled trial of antibiotics in children with chronic moist cough

A randomized double-blinded placebo-controlled trial of amoxycillin/clavulanic acid in children with chronic moist cough to improve cough scores.

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000533695

Enrollment

Registered

2005-09-28

Start date

2004-01-05

Completion date

2006-12-12

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This trial aims to assess the efficacy of antibiotics in treating children with a prolonged wet cough.

Interventions

Intervention is 14 days of oral amoxycillin/clavulanate 400mg/5ml suspension.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

6 Months to 14 Years

Healthy volunteers

Inclusion criteria

Children with chronic (>3 week duration) moist cough.

Exclusion criteria

Clinical or HRCT-proven bronchiectasis, gross neurodevelopmental delay, cystic fibrosis, known chronic disease such as interstitial lung disease or cardiac disease. Also children who have had antibiotic therapy in the preceding 2 weeks or who are allergic to penicillin will be excluded.

Outcome results