Healthy Volunteers for Heart Disease Research

Christchurch Healthy Volunteers for The Study of Heart Disease

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12605000448640

Enrollment

3400

Registered

2005-09-21

Start date

2002-01-07

Completion date

2025-12-31

Last updated

2024-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Heart disease results from the interaction of the genes we inherit and lifestyle factors, such as diet and smoking. To understand the role that genes play in the development of heart disease within the local population, the objective of the project is to collect blood samples from 6000 normal healthy individuals aged from 18 years selected from the Canterbury region, as a control group for our studies of heart disease. The age and gender profiles of the control group will be matched to those of patients who have had a heart attack or heart failure . The blood samples will be used as a source of DNA (genetic material) to allow determination of individual genetic profiles and associated levels of hormones and lipids in the circulation. The frequencies of gene variants thought to be involved in heart disease in the heart-disease patient groups will be compared with the control group to detect those genes which might contribute to an increased risk of to heart disease within the Canterbury population

Interventions

We will collect urine and blood samples for plasma and DNA/RNA from 6000 normal healthy individuals aged from 18-100 selected from the Canterbury region, for use as a control group for genetic association studies of cardiovascular and associated metabolic disease (eg diabetes). The age and gender profiles of the control group will be matched to those of the patients in the Christchurch Heart Institute observational and interventional studies of hypertension and heart disease.

Eligibility

Sex/Gender

All

Age

18 Not stated to No maximum

Healthy volunteers

Inclusion criteria

Potential participants will be selected at random from the electoral rolls covering the greater Christchurch area, including the Maori electorate of Te Tai Tonga.Individuals will be approached by mail initially with a letter and information sheet briefly explaining the study, inviting them to participate and asking them to supply information about their medical history.

Exclusion criteria

Exclusion of those that have a history of cardiovascular disease.

Outcome results