None listed
Conditions
Interventions
Autologous dendritic cell vaccine using autologous irradiated cells as antigen source administered at 2 weekly intervals for the first 6 injections, then 6 weekly thereafter, for 1 year or until disease progression.
Sponsors
Queensland Institute of Medical Research (QIMR)
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Treatment
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
1 Years to 75 Years
Healthy volunteers
No
Inclusion criteria
Confirmed Malignant Glioma, Macroscopic tumour resection, normal haematolological parameters, acceptable liver and renal function parameters.
Exclusion criteria
Extensive intracranial disease precluding total or subtotal resection, ECOG status >2, History of autoimmune disease or immunosuppressive therapy, Prior use of immunotherapeutic agent, Positive serology for HIV, Hep B or Hep C, Significant non-malignant disease, Pregnancy, Other malignancy, Patients in whom only biopsy or partial resection was possible.
Outcome results
None listed