None listed
Conditions
Interventions
Brain natriuretic peptide assay, transthoracic and transoesophageal echocardiography, clinical data and waveform analysis (including PaOP, CVP, pulse pressure variation and systolic pressure variation) will be performed immediately before and after rapid infusion of intravenous colloid solution.
Sponsors
University of Queensland
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Patient booked for CABG surgery.Left ventricular ejection fraction greater than 40% pre-operatively (as determined by echocardiography or radiocontrast ventriculography).Normal cardiac valvular function (defined as mitral or aortic valve regurgitation less than 2+ on echocardiography).Normal respiratory function (defined as absence of documented respiratory pathology or FEV1/FVC greater than or equal to 60%).Absence of oesophageal pathology that would contraindicate transoesophageal echocardiography.
Exclusion criteria
ECG demonstrates rhythm other than sinus rhythm or AAI pacing post-operatively.Pulmonary hypertension (defined as pulmonary systolic blood pressure greater than 50mmHg as estimated by echocardiography pre-operatively or by pulmonary artery catheter at the time of insertion).Blood loss greater than 250mL in the first hour post-operatively.
Outcome results
None listed