Towards better assessment and treatment of exercise induced wheeze

Comprehensive assessment of patients with exercise induced wheeze using pulmonary function testing, bronchial challenge testing (methacholine and Mannitol) and exhaled nitric oxide. A comparison of either inhaled steroids or a cross-over study of cromoglycate, montelukast and formoterol

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000397617

Enrollment

Registered

2005-09-14

Start date

2005-11-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Exercise induced symptoms are common especially in patients with asthma. There are several possible treatments for exercise induced wheeze. This study aims to provide further evidence to help GPs decide on which treatment is best for an individual patient

Interventions

Following comprehensive assessment, patients with exercise induced symptoms will be divided into two groups according to their baseline exhaled nitric oxide levels (FeNO). Those with a high FeNO (>35ppb) will receive inhaled fluticasone for 6 weeks.

Study design

Allocation

Randomised controlled trial

Intervention model

Crossover

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

12 Years to No maximum

Healthy volunteers

Inclusion criteria

Exercise induced wheeze, cough or dyspnoea are the primary symptoms.

Exclusion criteria

Current or recent ex-smokers, patients taking oral or inhaled steroids in the previous 6 weeks.

Outcome results