Improvements in insulin resistance caused by weight loss interventions

The effects of very-low calorie diet vs gastric bypass surgery on the metabolic profile of obese patients.

Status

Suspended

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000395639

Enrollment

Registered

2005-09-14

Start date

2006-03-09

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Forty volunteers will be randomised to receive either very-low calorie diet (VLCD)/Optifast or normal feeding regime prior to gastric bypass surgery. Twenty of these volunteers will be randomised to receive VLCD/Optifast by nasogastric tube for six days after surgery. Changes in insulin resistance will be measured by an insulin tolerance test before and after each intervention.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Patients presenting for gastric bypass and,BMI >35

Exclusion criteria

Significant known heart disease; significant renal disease; known liver disease; Type 1 diabetes; and,Type 2 diabetes for more than 5 years.

Outcome results