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SNAC Trial

A randomised phase III study to determine in women with early breast cancer whether sentinel node biopsy and axillary clearance if positive, results in less morbidity than immediate axillary clearance with equivalent cancer-related outcomes.

Status
Completed
Phases
Phase 3
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12605000357651
Acronym
SNAC Trial
Enrollment
1088
Registered
2005-09-09
Start date
2001-01-05
Completion date
2005-06-05
Last updated
2024-04-22

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

There are 32 active sites.

Interventions

Sentinel node biopsy with immediate standard axillary clearance vs sentinel node biopsy alone with axillary clearance if sentinel node is not identified or sentinel node is positive for cancer.

Sponsors

NHMRC
Lead SponsorGovernment body

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Open (masking not used)

Eligibility

Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No

Inclusion criteria

Histologically or cytologically confirmed invasive breast cancer.

Exclusion criteria

In situ cancer only. Clinically involved nodes where axillary surgery is deemed essential. Multicentric tumours. Primary tumour >3cm in diameter. Evidence of metastatic disease.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026