None listed
Conditions
Brief summary
To explore the potential of selenium incorporated in dairy proteins to improve health and reduce the risk of colon cancer.
Interventions
The aim is to explore the potential of selenium incorporated in dairy proteins to improve bowel health and reduce the risk of colon cancer. Participants will include a special dairy product in their diet in which the dairy proteins have been naturally enriched with selenium.
High selenium=100 micrograms per day, Placebo =1.5 micrograms selenium per day, in Milk protein concentrate prepared as a powdered food drink. Each intervention is 8 weeks in length with a 2 week wash-out between each phas
The aim is to explore the potential of selenium incorporated in dairy proteins to improve bowel health and reduce the risk of colon cancer. Participants will include a special dairy product in their diet in which the dairy proteins have been naturally enriched with selenium. High selenium=100 micrograms per day, Placebo =1.5 micrograms selenium per day, in Milk protein concentrate prepared as a powdered food drink. Each intervention is 8 weeks in length with a 2 week wash-out between each phase. Markers of the health value of selenium will then be examined in samples of blood and samples taken from the lining of the bowel wall. The duration of the intervention will be 2 weeks baseline+ 8 weeks for each treatment phase (16wks) and 2 weeks wash out between treatment phases.
Sponsors
Flinders Medical Centre
Study design
Allocation
Randomised controlled trial
Intervention model
Crossover
Primary purpose
Prevention
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Participants will be healthy, with no active bowel disease, or a previous history of adenoma removal >6 months ago, with plasma selenium at or below 95ug/dL.
Exclusion criteria
Any allergy or intolerance to milk/dairy products plasma Se above the 95th percentile of the current population (i.e. >95ug/dl), evidence of any active mucosal bowel disease, eg colitis, or of malabsorption, no evidence of any other active clinical disease.
Outcome results
None listed