None listed
Conditions
Interventions
Cough provocation using 3 different doses of nebulized capsaicin; cough provocation using eucapnic voluntary hyperpnea. One visit for each intervention will be required for the recruited patients.
Sponsors
Woolcock Institute of Medical Research
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Diagnosed with chronic cough that has been present for over 8 weeks, subjects with chronic cough will fall into two categories: cause of chronic cough is well-defined ie mild asthmatics, gastro-oesophageal reflux sufferers, rhinosinusitis sufferers, etc.; cause of chronic cough is obscure, and previous investigations have failed to identify a cause.
Exclusion criteria
Upper or lower airway infection in the past four weeks;Pregnancy: female participants of child bearing potential will be tested for pregnancy, by urine pregnancy test, before the capsaicin provocation, and if found to be pregnant will be excluded from the study; Smokers;Uncontrolled major diseases, including psychiatric disorders, heart conditions, high blood pressure or others deemed of significance by the investigator;People with any reported allergic reaction to pepper or ethanol.
Outcome results
None listed