Improving intestinal function after surgery

A prospective, randomised, double-blind, controlled trial examining the effects of prostaglandin inhibition on outcomes after intestinal surgery.

Status

Completed

Phases

Phase 3

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000299606

Acronym

POINT study

Enrollment

200

Registered

2005-09-05

Start date

2003-01-10

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

3 study groups; placebo, Diclofenac, Celecoxib given as a preoperative dose and continued until discharge, or 7 days postoperatively. All patients receive Pantoprazole 40 mg daily.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Patients underoing gastrointestinal surgery that involves intestinal manipulation (chiefly colorectal surgery). No recent history of gastrointestinal ulceration, intolerance to nonsteriodal antiflammatory drugs. Creatinine clearance greater than 30 ml/min. No requirement for postoperative ACE inhibitors.

Exclusion criteria

renal dysfuction, asthma, anticoagulants

Outcome results