Left ventricular diastolic function in lean and overweight subjects.

Status

Completed

Phases

Unknown

Study type

Observational

Source

ANZCTR

Registry ID

ACTRN12605000298617

Acronym

LOVE

Enrollment

Registered

2005-09-05

Start date

2004-10-21

Completion date

2006-01-25

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This cross-sectional (snapshot) study aims to measure the relaxation function of the heart (using ultrasound) in a group of people who do not have diabetes, who are of varying weight and body size (ranging from lean to overweight).

Interventions

A cross-sectional observational study of left ventricular diastolic function in non-diabetic subjects over a range of body mass. No treatment intervention.

Eligibility

Sex/Gender

All

Age

40 Years to 79 Years

Healthy volunteers

Inclusion criteria

Subjects without diabetes (excluded by oral glucose tolerance test); lean subjects (BMI<25kg/m2) with waist circumference <94cm for men and <88cm for women; overweight subjects (BMI 25kg/m2 or greater) with waist circumference 94cm or greater for men and 88cm or greater for women.

Exclusion criteria

Atrial fibrillation; abnormal thyroid function; history of cardiovascular disease (myocardial or cerebral ischaemia); other major systemic illness. Lean subjects: impaired glucose tolerance, blood pressure>140/80mmHg, fasting total cholesterol 6.0mmol/L or greater; fasting triglycerides 2.2mmol/L or greater; treatment for hypertension or dyslipidaemia. Overweight subjects: blood pressure 150/90mmHg or greater; fasting total cholesterol>7.0mmol/L; fasting triglycerides>4.0mmol/L.

Outcome results