The effect of calcium supplementation on lipids and bone density in men.

The effect of calcium supplementation on serum lipids and bone density in normal men.

Status

Completed

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000274673

Enrollment

300

Registered

2005-09-02

Start date

2004-04-15

Completion date

2005-07-26

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

This is a 2 year study designed to determine the effect 1g of calcium supplements daily on lipids and bone density in men.

Interventions

Daily 600mg calcium (as the citrate) or 1200mg calcium (as the citrate) over 2 years.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

Male

Age

40 Years to No maximum

Healthy volunteers

Inclusion criteria

Males, Age > 40 years, Life expectancy > 5 years.

Exclusion criteria

Coronary heart disease, Diabetes, 5 yr predicted cardiovascular risk of > 15%, Renal impairment (serum creatinine > 0.2mmol/l), Untreated hypo- or hyperthyroidism Active liver disease Serum 25-hydroxyvitamin D < 25 nmol/l Concurrent major systemic disease, including malignancy, Metabolic bone disease, Current treatment for hyperlipidaemia or osteoporosis, Regular use of testosterone replacement therapy within the previous 1 year, Regular use of anabolic steroid preparations in the previous 1 year, Treatment with bisphosphonates in the previous 1 year, Treatment with glucocorticoid drugs in the previous year, Lumbar spine bone density < mean-2.0 SD for age-appropriate data (ie: Z score < -2).

Outcome results