A comparison of topical anaesthesia with placebo for the managment of minor corneal trauma.

Topical anaesthesia (does / does not) delay re-epithelialisation after minor corneal trauma.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000273684

Acronym

MOTE - Minor Ocular Trauma in

Enrollment

Registered

2005-09-02

Start date

2006-05-02

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

A pilot study to investigate the safety of using local anaesthetic eye drops to control pain following minor corneal injuries.

Interventions

Dispensing 1.5 mL of eye drops, 0.4% amethocaine, for out-patient management of ocular pain in the first 48hr following the initial emergency department presentation with corneal abrasion, corneal foreign body or UV keratitis.

Study design

Allocation

Randomised controlled trial

Intervention model

Single group

Primary purpose

Treatment

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

(a) Superficial corneal abrasion with clear history of trauma; (b) superficial corneal abrasion with foreign body; or (c) ultraviolet keratitis with clear history of welding flash exposure.

Exclusion criteria

(a) 36hr or more since event causing the corneal injury; (b) aged under 18yr; (c) history of any of - unacceptable adverse reaction to any local anaesthetic agent or to any ophthalmic preparation, visual impairment secondary to another eye pathology other than simple refractive error, contact lens use, previous participation in this trial, or current pregnancy/lactation; (d) signs of conjunctival infection; (e) functionally one-eyed; or (f) patient requiring referral for ophthalmological opinion.

Outcome results