None listed
Conditions
Interventions
Subjects will be exposed to short term hypoxia aiming for a target saturation of 80% while haemodynamic and ventilatory parameters are measured. They will breathe through a mouthpiece connected to special equipment which delivers different gas mixtures and enables the delivery of the hypoxic exposure. Heart rate, blood pressure, arterial stiffness ( via pulse wave analysis), and peripheral vasoconstriction (via peripheral arterial tonometry PAT) will be measured. Initially there will be a 10
Subjects will be exposed to short term hypoxia aiming for a target saturation of 80% while haemodynamic and ventilatory parameters are measured. They will breathe through a mouthpiece connected to special equipment which delivers different gas mixtures and enables the delivery of the hypoxic exposure. Heart rate, blood pressure, arterial stiffness ( via pulse wave analysis), and peripheral vasoconstriction (via peripheral arterial tonometry PAT) will be measured. Initially there will be a 10 minute baseline period followed by the 20 minute period of hypoxia and then a 10 minute recovery period. A proportion of subjects will then be studied after being commenced on treatment with continuous positive airway pressure (CPAP).
Sponsors
NHMRC
Study design
Allocation
Non-randomised trial
Intervention model
Single group
Primary purpose
Diagnosis
Masking
Open (masking not used)
Eligibility
Sex/Gender
Male
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Severe OSA based on polysomnography (Respiratory Disturbance Index (RDI) 25 ).
Exclusion criteria
History of other cardiovascular or respiratory disease including hypertension, hypercholesterolemia, ischaemic heart disease or diabetesSmoker Treatment with cardiovascular or respiratory medication.
Outcome results
None listed