Metformin in Gestational Diabetes

Gestational Diabetes: pregnancy outcomes in treatment with metformin compared with insulin.

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000266662

Acronym

MiG

Enrollment

750

Registered

2005-09-02

Start date

2002-10-01

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Women who require treatment for GDM are randomsied to insulin or metformin treatment to test the hypothesis that metformin compared with insulin is associated with similar neonatal morbidity, improved markers of insulin sensitivty in mother and offspring and improved treatment acceptability. The trial has been running betwee 1-3 years at each centra and should finish recruiting in September 2006

Interventions

Women with gestational diabetes requiring treatment are randomised to insulin or metformin treatment for the duration of pregnancy.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

18 Years to 45 Years

Healthy volunteers

Inclusion criteria

22-33 weeks' gestation, singleton pregnancy, capillary glucose levels requiring additional treatment.

Exclusion criteria

Diabetes diagnosed pregnancy, gestational hypertension, pre-eclampsia of fetal growth restriction at study entry, fetal congenital anomaly, maternal medical conditon posing contra-indication to metformin.

Outcome results