None listed
Conditions
Brief summary
To find the undiscovered gene or genes responsible for hereditary colorectal cancer, and to understand how the gene(s) cause colorectal cancer.
Interventions
The aim of this research is to find the undiscovered gene or genes responsible for hereditary colorectal cancer, and to understand how the gene(s) cause colorectal cancer. One of the best approaches used to find the answers to these questions is to study families where there are several family members affected with colorectal cancer.
Case probands and their relatives (affected and unaffected) will be recruited
(20 ml) of blood will be obtained on one occasion from each participant
Where tissues
The aim of this research is to find the undiscovered gene or genes responsible for hereditary colorectal cancer, and to understand how the gene(s) cause colorectal cancer. One of the best approaches used to find the answers to these questions is to study families where there are several family members affected with colorectal cancer. Case probands and their relatives (affected and unaffected) will be recruited (20 ml) of blood will be obtained on one occasion from each participant Where tissues from affected family members have already been obtained (paraffin embedded tumour tissue in blocks) we will seek permission to access this material for DNA extraction. The duration of study will be approximately 48 months.
Sponsors
CSIRO, Australia
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Cancer patients:1: Patients from families with 3 or more first-degree relatives having CRC, with one diagnosed less than 50 years of age. 2: Patients from families with 2 or more first-degree relatives having CRC. 3: Patients from families with one first degree and one or more second-degree relatives having CRC.Unaffected Individuals:1: First-degree relatives, over 70 years of age, from the above families who have no history of colorectal neoplasia.2:Younger first-degree relatives, at least 50 years of age, who are colonoscopy negative.
Exclusion criteria
No exclusion criteria
Outcome results
None listed