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Muscle Strength vs. Muscle Endurance Training for Osteoarthritis of the Knee in Older Adults; A double-blind, randomized sham exercise-controlled trial

A double-blinded randomised clinical trial to evaluate the effects of muscle strength training, or muscle endurance training compared with sham exercise training in the treatment of osteoarthritic-related pain.

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ANZCTR
Registry ID
ACTRN12605000230651
Enrollment
75
Registered
2005-08-26
Start date
2004-03-01
Completion date
Unknown
Last updated
2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Patients were randomised to one of the following for 8 weeks: 1) Endurance training group, 2) Strength training group

Sponsors

University of Sydney
Lead SponsorUniversity

Study design

Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)

Eligibility

Sex/Gender
All
Age
50 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Primary (idiopathic) osteoarthritis of hip &/or knee identified using standard criteria of the American College of Rheumatology for classification of clinical osteoarthritis (pain of the knee or hip on most days of the past month, morning stiffness by history; crepitus, bony enlargement of the knee, pain or limitation of motion on internal rotation of the hip on exam, or radiographic evidence of osteophytes or joint space narrowing from medical record review). pain of at least mild intensity (>25 on a 100mm visual analog scale). Community-dwelling (living independently) ambulatory without human assistance. Willingness to be randomised to experimental or control groupsAbility to attend scheduled exercise and testing sessions.

Exclusion criteria

Regular exercise of any kind over the past 6 months (1dpw). Secondary osteoarthritis (traumatic or post-surgical), rheumatic disease, gouty or septic arthritis, Paget's disease, pseudogout, major congenital abnormalities, hemachromatosis, Wilson's disease and other rare forms of arthritis Joint injury, injection or surgery within the past 6 months or joint replacement. Acute or terminal illness. Unstable systemic disease precluding exercise such asAcute myocardial infarction in the past 6 months. Unstable cardiovascular disease (angina, cardiac arrhythmias, hypertension). Uncontrolled diabetes or other metabolic disease.Disorders of the nervous system disrupting voluntary movement (cerebrovascular accident/stroke with residual paresis, Parkinson's disease, demyelination disorders - multiple sclerosis). Severe functional limitation (unable to walk unaided). Musculoskeletal disease/injury severely restricting voluntary movement. (severe arthritis/ankylosis, pain related to osteoporotic vertebral crush fractures, rotator cuff disease/injury). Cognitive impairment Other contra-indication to exercise as assessed during the screening history and physical examination by a study physician.

Outcome results

None listed

Source: ANZCTR · Data processed: Feb 4, 2026