The GABA Study

Single-dose Pregabalin in Postoperative Pain Relief after Minor Gynaecological Surgery

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000223639

Enrollment

Registered

2005-08-26

Start date

2005-08-08

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Women undergoing D&C surgery often experience pain afterwards between 2 and 7 on a scale of 1-10. This pain is intially due to surgical trauma but may continue because of resulting inflammation. If the ongoing cycle of inflammation is reduced pain may be less. Pregabalin is a treatment for seizure disorders. It also has pain relieving and calming properties. It can reduce local tissue inflammation and the release of pain mediators. Therefore pregabalin given preoperatively may reduce postoperative pain.

Interventions

Single-dose pregabalin 100 mg administered 1-2 hours pre-operatively, effect on postoperative pain assessed.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Prevention

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

0 to No maximum

Healthy volunteers

Inclusion criteria

Undergoing minor gynaecological surgery on uterus/cervix without skin or mucosal incision, i.e. D&C +/- Hysteroscopy. ASA 1 or 2.

Exclusion criteria

Allergy to pregabalin.History of chronic pelvic pain.Receiving preoperative misoprostol.Currently taking opioids or other forms of pain relief, sedatives or anticonvulsants.Preoperative history of dizziness or severe headaches.Petient request for sedative/anxiolytic premedication.

Outcome results