Propofol induction in cannabis using patients

Dose of Propofol for induction of general anaesthesia in cannabis using patients

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000221651

Acronym

PICUP

Enrollment

Registered

2005-08-26

Start date

2005-07-01

Completion date

2007-12-31

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Brief summary

Trial completed and published 2009 Flisberg P, Paech MJ, Shah T, Ledowski T, Kurowski I, Parsons R. Induction dose of propofgol in patients using cannabis. Euro J Anaesthesiol 2009;26:192-5

Interventions

The dose of propofol required to induce general anaesthesia will be compared in cohorts of patients who use cannabis regularly and those who do not use it at all. The duration of the intervention is 90 seconds, the time required to reach or not reach primary endpoint of unconsciousness.

Study design

Allocation

Randomised controlled trial

Intervention model

Parallel

Primary purpose

Diagnosis

Masking

Blinded (masking used)

Eligibility

Sex/Gender

All

Age

18 Years to 50 Years

Healthy volunteers

Inclusion criteria

LMA anaesthesia, ASA 1-2.

Exclusion criteria

Weight >100kgs, cardiovascular disease, use of opiod,cocaine or amphetamines,benzodiazepine & SSRI use, allergy to propofol,alcohol abuse, anti retro-viral therapy, unstable pre-induction BIS value.

Outcome results