None listed
Conditions
Interventions
The study will be conducted over a 6-8 day period during a hospital admission for hypercapnic respiratory failure. On day 1, baseline anthropometric data, measurement of exercise capacity, quality of life, an arterial blood gas, spirometry and maximum inspiratory and expiratory muscle pressures at the mouth were collected. Day 2 subjects were randomised to either a control or early exercise rehabilitation with supplemental oxygen or early exercise rehabilitation group (with non-invasive ventilat
The study will be conducted over a 6-8 day period during a hospital admission for hypercapnic respiratory failure. On day 1, baseline anthropometric data, measurement of exercise capacity, quality of life, an arterial blood gas, spirometry and maximum inspiratory and expiratory muscle pressures at the mouth were collected. Day 2 subjects were randomised to either a control or early exercise rehabilitation with supplemental oxygen or early exercise rehabilitation group (with non-invasive ventilation and supplemental oxygen). All groups receive standard medical care, including non-invasive ventilation at rest as required. Early rehabilitation consists of a supervised, progressive exercise program of approximately 20-30 minutes each day for at least 4 days. Day 6-8 baseline measures repeated.
Sponsors
Royal Prince Alfred Hospital, Woolcock Institute of Medical Research, University of Sydney
Study design
Allocation
Randomised controlled trial
Intervention model
Parallel
Primary purpose
Treatment
Masking
Blinded (masking used)
Eligibility
Sex/Gender
All
Age
0 to No maximum
Healthy volunteers
No
Inclusion criteria
Daytime PaCO2 greater than 45mmHg, pH greater than 7.34, 3 out of 4 of : increase in FiO2 required to maintain SpO2 greater than 90% compared to baseline, increase in dyspnoea in the past week, increase in cough/sputum past week, decrease in subjective exercise tolerance over past week.
Exclusion criteria
pH equal to or less than 7.34, gross hypoxaemia, unstable angina or myocardial infarct in previous month, uncontrolled hypertension, febrile, resting tachycardia, orthopaedic or neurological conditions that limit exercise capacity, decreased level of conciousness, major psychiatric illness.
Outcome results
None listed