THE EFFECT OF AN ALGORITHM BASED SEDATION GUIDELINE ON THE DURATION OF MECHANICAL VENTILATION FOR INTENSIVE CARE PATIENTS IN AN AUSTRALIAN INTENSIVE CARE UNIT

THE EFFECTS OF AN ALGORITHM BASED SEDATION GUIDELINE ON THE DURATION OF MECHANICAL VENTILATION FOR INTENSIVE CARE PATIENTS IN AN AUSTRALIAN INTENSIVE CARE UNIT

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ANZCTR

Registry ID

ACTRN12605000158662

Enrollment

322

Registered

2005-08-15

Start date

2002-01-11

Completion date

Unknown

Last updated

2020-01-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

The intervention (a sedation guideline previously found to be beneficial) was tested in a quasi-experimental preintervention study (n=322). The study was conducted in two phases, a ten-month preintervention data collection phase (November 2002 to October 2003) was followed by a twelve-month postintervention phase (November 2003 to December 2004).

Study design

Allocation

Non-randomised trial

Intervention model

Other

Primary purpose

Treatment

Masking

Open (masking not used)

Eligibility

Sex/Gender

All

Age

17 Years to No maximum

Healthy volunteers

Inclusion criteria

Research participants were selected on the basis of whether they were mechanically ventilated while they were in intensive care. Participants were eligible for inclusion if they were adults older than 17 years.

Exclusion criteria

Patients were excluded if they: i) had a primary diagnosis of head injury or other neurological insult and where the aim of sedation was to reduce or minimise intracranial pressure and/or cerebral artery spasm.ii) were not expected to live for more than 24 hours after admission, e.g. patients who had a diagnosis of brain stem death or who were likely to require brain stem death tests.iii) had an explicit ventilation weaning goal on admission e.g. post operative coronary artery bypass graft patients recovering from general anaesthetic.iv) were likely to be ventilated for more than 21 days, e.g. patients with neurological conditions such as Guillain-Barre Syndrome and myasthenia gravis, and patients who had sustained a recent complete spinal cord lesion above cervical spine vertebra number five.v) had previously been enrolled in the study and were readmitted to the intensive care unit more than 72 hours after they were discharged. However for the purpose of this project patients who were readmitted within 72 hours were regarded as being in the same ICU admission.vi) had sustained a burn injury covering more than 15% of their body surface area.

Outcome results